Ver contra-indicações. Os aumentos de ALT com o regime de VHC ombitasvir/paritaprevir/ritonavir, com ou sem dasabuvir; interromper Nuvaring antes do início do regime de VHC e reiniciar 2wks após a conclusão do tratamento. Não utilizar com métodos femininos de barreira (por exemplo, diafragma, tampa cervical, preservativo feminino); o dispositivo de anel pode interferir com a sua colocação e posição., Antagonized by hepatic enzyme inducing drugs (eg, phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, topiramate, rifabutin, rufinamide, aprepitant, St. John’s wort); use non-hormonal method or a backup contraception. May be potentiated by atorvastatin, acetaminophen, ascorbic acid, vaginal miconazole, or strong/moderate CYP3A4 inhibitors (eg, itraconazole, ketoconazole, voriconazole, fluconazole, grapefruit juice). May be affected by HIV/HCV protease inhibitors or NNRTIs., May antagonize acetaminophen, temazepam, salicylic acid, morphine, clofibric acid, lamotrigine. May potentiate cyclosporine, prednisolone, theophylline, tizanidine, voriconazole. May need dose adjustment of thyroid hormones. May affect lab tests (eg, coagulation factors, lipids, glucose tolerance, binding proteins, hormone binding globulins).